BIO-PLY™ is a specialized formulation of platelet-rich plasma (PRP). PRP is a biologic made from whole blood where white and red blood cells have been removed, leaving concentrated platelets in plasma. In addition to their well-known role in coagulation, platelets are also important players in host defense and immunity. In fact, when platelets are activated, they release a milieu of bioactive factors that are directly antimicrobial, modulate immune responses, dampen inflammation and promote tissue healing.

In the past, most PRP was made from the patient’s own whole blood. However, when patients are ill, aged, or stressed their PRP quality can decline. Therefore, we have developed BIO-PLY™ to be made from healthy, young blood donors that have been proven to make high quality PRP. Then we pool the PRP from multiple donors and concentrate platelets to maximize the number of bioactive factors. This proprietary process vastly decreases the variability and increases the potency over regular PRP.

Since the platelets are simply transport mechanisms for the bioactive factors they carry, we designed BIO-PLY™ to be acellular, removing the possibility of host rejection.

The BIO-PLY™ process results in thousands of bioactive factors from both platelets and plasma. To guarantee against a hypersensitivity response in a recipient we removed all the factors that could be potentially harmful, leaving only the factors that are responsible for the powerful antimicrobial, immunomodulatory, anti-inflammatory, and regeneration effects of BIO-PLY™.